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We go nuts for gonads
At the Siegfried laboratory, we investigate genetic regulation underlying development of the gonad. How do germ cells develop to form functional gametes and how are these differences between the sexes manifested during development? Answering these questions helps us uncover the underlying developmental processes that are essential for fertility and reproduction
Research aims
Research aims
We examine how germ cells develop to form functional gametes and how differences between the sexes are manifested during development. These developmental processes are necessary for fertility and reproduction. We use the zebrafish model to ask several fundamental questions in reproductive development:
1. How does the testis continuously produce a new supply of sperm in a controlled fashion to maintain fertility throughout life?
2. How are two sexes determined and how does each sex differentiate distinct cell types?
3. How do the male gametes develop from undifferentiated diploid germ cells into highly specialized haploid sperm?
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